{"id":40875,"date":"2019-11-21T13:22:17","date_gmt":"2019-11-21T12:22:17","guid":{"rendered":"https:\/\/www.fertilitycenter.it\/?p=40875"},"modified":"2019-11-21T13:22:17","modified_gmt":"2019-11-21T12:22:17","slug":"membrane-amnio-coriali-fisiopatologia","status":"publish","type":"post","link":"https:\/\/www.fertilitycenter.it\/gravidanza\/membrane-amnio-coriali-fisiopatologia","title":{"rendered":"Membrane amnio-coriali: fisiopatologia"},"content":{"rendered":"<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-size: 14pt\">Le membrane amnio-coriali sono due formazioni connettivali fibrose, sottili e trasparenti: corion e amnios\u00a0 che si sviluppano dall’embrione. Assieme a\u00a0<\/span><span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-size: 18.6667px;font-style: normal;font-weight: 400\">cordone ombelicale, sacco vitellino e allantoide costituiscono le\u00a0<\/span><span style=\"font-family: 'arial black', sans-serif;font-style: normal;font-weight: 400;font-size: 18.6667px\">\u00a0<span style=\"color: #000000\">membrane fetali.<\/span><\/span><\/p>\n<p><a href=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/membrane-amnio-coriali-schema-1.png\" data-rel=\"penci-gallery-image-content\" ><img decoding=\"async\" class=\"aligncenter size-full wp-image-40976\" src=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/membrane-amnio-coriali-schema-1.png\" alt=\"\" width=\"628\" height=\"436\" srcset=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/membrane-amnio-coriali-schema-1.png 628w, https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/membrane-amnio-coriali-schema-1-300x208.png 300w\" sizes=\"(max-width: 628px) 100vw, 628px\" \/><\/a><\/p>\n<p> <\/p>\n<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-style: normal;font-weight: 400;font-size: 18.6667px\">Le membrane amnio-coriali, dal 4\u00b0 messe si accollano ed<\/span><span style=\"font-size: 14pt\">\u00a0\u00a0<\/span><span style=\"font-size: 14pt\"><strong><span style=\"font-family: 'comic sans ms', sans-serif\">avvolgono il\u00a0feto e il cordone ombelicale<\/span><\/strong>. Il\u00a0<i>corion<\/i>\u00a0presenta uno spessore di circa 1 millimetro (una sua parte \u00e8 differenziata a formare la\u00a0placenta), internamente al corion si trova la membrana amniotica \u00e8 molto pi\u00f9 sottile del corion.\u00a0\u00a0<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-size: 14pt\">Fino alla 8-9<sup>a<\/sup> settimana le due membrane sono nettamente separate dalla cavit\u00e0 coriale.<\/span><\/p>\n<p><a href=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/membrane-amnio-coriali-2.png\" data-rel=\"penci-gallery-image-content\" ><img decoding=\"async\" class=\"aligncenter size-full wp-image-40945\" src=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/membrane-amnio-coriali-2.png\" alt=\"\" width=\"574\" height=\"420\" srcset=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/membrane-amnio-coriali-2.png 574w, https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/membrane-amnio-coriali-2-300x220.png 300w\" sizes=\"(max-width: 574px) 100vw, 574px\" \/><\/a><\/p>\n<p> <\/p>\n<p> <\/p>\n<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-size: 14pt\">In seguito le due membrane si accostano progressivamente con l’avanzare dell’epoca gestazionale\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/Membrane-amniotiche-a-13settimane.png\" data-rel=\"penci-gallery-image-content\" ><img decoding=\"async\" class=\"aligncenter size-full wp-image-40936\" src=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/Membrane-amniotiche-a-13settimane.png\" alt=\"\" width=\"574\" height=\"402\" srcset=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/Membrane-amniotiche-a-13settimane.png 574w, https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/Membrane-amniotiche-a-13settimane-300x210.png 300w\" sizes=\"(max-width: 574px) 100vw, 574px\" \/><\/a><\/p>\n<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-size: 18.6667px;font-style: normal;font-weight: 400\">Dalla 13<sup>a<\/sup> settimana le due membrane\u00a0<\/span><span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-size: 18.6667px;font-style: normal;font-weight: 400\">\u00a0si fondono<\/span><span style=\"font-size: 14pt\">\u00a0in conseguenza\u00a0del fatto che la cavit\u00e0 amniotica si ingrandisce molto pi\u00f9 rapidamente del sacco coriale.\u00a0<\/span><span style=\"font-size: 14pt\"><span style=\"font-family: 'comic sans ms', sans-serif\"><strong><span style=\"font-family: 'arial black', sans-serif\">La fusione tra la\u00a0<i>membrana\u00a0<\/i><i>amniotica<\/i>\u00a0e quella\u00a0<i>coriale<\/i>\u00a0avviene durante il 3-4\u00b0 mese di gravidanza.<\/span> <\/strong>Tra i due foglietti rimane solo un sottile strato di tessuto areolare.<\/span><\/span><\/p>\n<p><a href=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/Membrane-amniocoriali-fuse.png\" data-rel=\"penci-gallery-image-content\" ><img decoding=\"async\" class=\"aligncenter size-full wp-image-40953\" src=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/Membrane-amniocoriali-fuse.png\" alt=\"\" width=\"744\" height=\"460\" srcset=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/Membrane-amniocoriali-fuse.png 744w, https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2019\/11\/Membrane-amniocoriali-fuse-300x185.png 300w\" sizes=\"(max-width: 744px) 100vw, 744px\" \/><\/a><\/p>\n<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-size: 14pt\">In seguito la membrana coriale si fonde con la\u00a0<i>decidua<\/i>\u00a0<i>capsulare<\/i>, e poi quest\u2019ultima con la\u00a0<i>decidua<\/i>\u00a0<i>parietale<\/i>, cos\u00ec che verso la fine del 3\u00b0 mese la cavit\u00e0 dell\u2019utero\u00a0risulta obliterata. Alla fine del\u00a0parto, le membrane amnio-coriali sono espulse assieme alla placenta.<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-family: 'arial black', sans-serif;font-size: 14pt\"><span style=\"color: #000000\">Funzione selle membrane amnio-coriali:<\/span>\u00a0<\/span><span style=\"font-size: 14pt\">La loro <span style=\"font-family: 'comic sans ms', sans-serif\"><strong>funzione<\/strong><\/span> sembra essere, oltre che <span style=\"font-family: 'comic sans ms', sans-serif\"><strong>protettiva<\/strong><\/span> anche <span style=\"font-family: 'comic sans ms', sans-serif\"><strong>secernente<\/strong><\/span>, nei confronti del\u00a0ricambio\u00a0di <a href=\"https:\/\/www.fertilitycenter.it\/gravidanza\/liquido-amniotico-2\">liquido amniotico<\/a>, <span style=\"font-family: 'comic sans ms', sans-serif\"><strong>e metabolica<\/strong><\/span> dato che regolano lo scambio di alcune sostanze nutritive tra compartimento materno e fetale.<\/span><\/p>\n<p style=\"padding-left: 30px\"><span style=\"font-size: 14pt;color: #000000\"><strong><span style=\"font-family: 'comic sans ms', sans-serif\">PATOLOGIE DELLE MEMBRANE –<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-size: 14pt\"><span style=\"font-family: 'arial black', sans-serif;color: #000000\"><strong>Amnion<\/strong> <strong>Nodosum<\/strong><\/span>\u00a0\u00e8 una lesione nodulare della superficie dell’amnios sul piatto coriale o attorno al cordone ombelicale. I noduli sono costituiti da multiple <a href=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2015\/02\/Amnion-nodosum1.png\" data-rel=\"penci-gallery-image-content\" ><img decoding=\"async\" class=\"alignleft size-full wp-image-20171\" src=\"https:\/\/www.fertilitycenter.it\/wp-content\/uploads\/2015\/02\/Amnion-nodosum1.png\" alt=\"\" width=\"227\" height=\"201\" \/><\/a>aggregazioni di cellule squamose epiteliali derivate dalla vernice caseosa e detriti cellulari. I noduli,\u00a0<span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-style: normal;font-variant: normal;line-height: 17.68px\">di colorito giallastro,<\/span><span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-style: normal;font-variant: normal;line-height: 17.68px\">\u00a0<\/span>presentano un diametro di \u00a0circa 2 mm di grandezza. Si riscontra frequentemente nell\u2019<a href=\"https:\/\/www.fertilitycenter.it\/eco\/liquido-amniotico\"><span style=\"font-family: 'comic sans ms', sans-serif;color: #000000\"><strong>oligoidramnios<\/strong><\/span><\/a>, nelle anomalie genito-urinarie del neonato, nella <a href=\"https:\/\/www.fertilitycenter.it\/gravidanza\/gravidanza-gemellare\"><strong><span style=\"font-family: 'comic sans ms', sans-serif\">sindrome \u00a0twin-twin transfusion<\/span><\/strong><\/a>, <a href=\"https:\/\/www.fertilitycenter.it\/gravidanza\/morte-improvvisa-fetale\"><span style=\"font-family: 'comic sans ms', sans-serif\"><strong>morte fetale<\/strong><\/span><\/a>, \u00a0e nella <span style=\"color: #000000\"><strong><span style=\"font-family: 'comic sans ms', sans-serif\">rottura prolungata delle membrane (PROM)<\/span><\/strong> <\/span>(1-4).<\/span><\/p>\n<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-size: 14pt\"><span style=\"font-family: 'comic sans ms', sans-serif;color: #000000\"><strong><span style=\"font-family: 'arial black', sans-serif\">Le vestigia del sacco vitellino e dell’<a href=\"https:\/\/www.fertilitycenter.it\/anatomia\/allantoide-2\">allantoide<\/a>:\u00a0<\/span> <\/strong><\/span>si presentano come dei piccoli corpi giallastri e rotondi e vengono trovati sull\u2019amnios nella zona di inserzione del cordone. <\/span><\/p>\n<p style=\"text-align: justify;padding-left: 30px\"><span style=\"font-size: 14pt\"><span style=\"font-family: 'arial black', sans-serif;color: #000000\">Metaplasia squamosa dell’amnios\u00a0<\/span><\/span><span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-size: 18.6667px;font-style: normal;font-weight: 400\">vicino al cordone ombelicale\u00a0<\/span><span style=\"font-size: 14pt\">in forma di placche di colorito grigiastro-chiaro sulla superficie dell\u2019amnios; l\u2019esame microscopico rivela cellule epidermoidi cheratinizzate.<\/span><\/p>\n<p style=\"padding-left: 30px\"><a href=\"https:\/\/www.fertilitycenter.it\/gravidanza\/rottura-prematura-delle-membrane-prom\"><span style=\"font-size: 14pt\"><strong><span style=\"font-family: 'comic sans ms', sans-serif\">Rottura prematura delle membrane (PROM)<\/span><\/strong><\/span><\/a><\/p>\n<p style=\"padding-left: 30px\"><strong><span style=\"font-size: 14pt;color: #000000\">References:<\/span><\/strong><\/p>\n<ol>\n<li style=\"text-align: justify\"><span style=\"font-size: 14pt;color: #000000\"><span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;line-height: 1.625\">Adeniran AJ, Stanek J, (2007). “Amnion nodosum revisited: clinicopathologic and placental correlations”.\u00a0<\/span><em>Arch Pathol Lab Med<\/em><span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;line-height: 1.625\">\u00a0<\/span><strong>131<\/strong><span style=\"font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;line-height: 1.625\">\u00a0(12): 1829\u201333<\/span><\/span><\/li>\n<li style=\"text-align: justify\"><span style=\"color: #000000;font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-size: 14pt;font-style: normal;font-variant: normal;line-height: 17.68px;background-color: #f5f5f5\">Adeniran, A. and J. Stanek .\u00a0Amnion nodosum revisited: clinicopathologic and placental features.\u00a0Presented at: 50th Annual Meeting of the Paediatric Pathology Society; April 22\u201324, 2004; Cape Town, South Africa.<\/span><\/li>\n<li style=\"text-align: justify\"><span style=\"color: #000000;font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-size: 14pt;font-style: normal;font-variant: normal;line-height: 17.68px;background-color: #f5f5f5\">Stanek, J. and A. Adeniran .\u00a0Chorion nodosum: a placental feature of the severe early amnion rupture sequence.\u00a0Pediatr Dev Pathol\u00a02006. 9:353\u2013360.<\/span><\/li>\n<li style=\"text-align: justify\"><span style=\"font-size: 14pt\"><span style=\"color: #000000;font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-style: normal;font-variant: normal;line-height: 17.68px\">Faye-Petersen, O. M. , D. S. Heller , and V. V. Joshi .\u00a0<\/span><span style=\"color: #000000\"><em>Handbook of Placental Pathology.<\/em><\/span><span style=\"color: #000000;font-family: 'Helvetica Neue', Helvetica, Arial, 'Lucida Grande', sans-serif;font-style: normal;font-variant: normal;line-height: 17.68px\">\u00a02nd ed.\u00a0London, England: Taylor and Francis; 2006.<\/span><\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Le membrane amnio-coriali sono due formazioni connettivali fibrose, sottili e trasparenti: corion e amnios\u00a0 che si sviluppano dall’embrione. Assieme a\u00a0cordone ombelicale, sacco vitellino e allantoide costituiscono le\u00a0\u00a0membrane fetali. Le…<\/p>\n","protected":false},"author":3,"featured_media":40936,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[443,3985,6635],"class_list":["post-40875","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gravidanza","tag-amnion-nodosum","tag-metaplasia-squamosa-dellamnios","tag-vestigia-del-sacco-vitellino"],"_links":{"self":[{"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/posts\/40875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/comments?post=40875"}],"version-history":[{"count":0,"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/posts\/40875\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/media\/40936"}],"wp:attachment":[{"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/media?parent=40875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/categories?post=40875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fertilitycenter.it\/wp-json\/wp\/v2\/tags?post=40875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}